5,706 research outputs found
What do gas-rich galaxies actually tell us about modified Newtonian dynamics?
It has recently been claimed that measurements of the baryonic Tully-Fisher
relation (BTFR), a power-law relationship between the observed baryonic masses
and outer rotation velocities of galaxies, support the predictions of modified
Newtonian dynamics for the slope and scatter in the relation, while challenging
the cold dark matter (CDM) paradigm. We investigate these claims, and find
that: 1) the scatter in the data used to determine the BTFR is in conflict with
observational uncertainties on the data; 2) these data do not make strong
distinctions regarding the best-fit BTFR parameters; 3) the literature contains
a wide variety of measurements of the BTFR, many of which are discrepant with
the recent results; and 4) the claimed CDM "prediction" for the BTFR is a gross
oversimplification of the complex galaxy-scale physics involved. We conclude
that the BTFR is currently untrustworthy as a test of CDM.Comment: 5 pages, 2 figures; minor revisions to match published versio
Novel methods for spatial prediction of soil functions within landscapes (SP0531)
Previous studies showed that soil patterns could be predicted in agriculturally managed landscapes by modelling and extrapolating from extensive existing but related integrated datasets. Based on these results we proposed to develop and apply predictive models of the relationships between environmental data and known soil patterns to predict capacity for key soil functions within diverse
landscapes for which there is little detailed underpinning soil information available.
Objectives were:
To develop a high-level framework in which the non-specialist user-community could explore questions.
To generate digital soil maps for three selected catchments at a target resolution of 1:50000 to provide the base information for soil function prediction.
To use a modelling approach to predict the performance of key soil functions in catchments undergoing change but where only sparse or low resolution soil survey data are available.
To use a modelling approach to assess the impact of different management scenarios and/or environmental conditions on the delivery of multiple soil functions within a catchment.
To create a detailed outline of the requirements for ground-truthing to test the predicted model outputs at a catchment scale.
To contribute to the development of a high-level framework for decision makers
In vitro assessment of Clostridium difficile PCR ribotype 002: the most prevalent C. difficile ribotype in the United Kingdom.
Simon Baines, Iye Ameh, Jane Freeman, W.N. Fawley, M.H. Wilcox, ‘In vitro assessment of Clostridium difficile PCR ribotype 002: the most prevalent C. difficile ribotype in the United Kingdom’, poster presented at the 25th European Congress on Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark, 25-28 August, 2015.Background: Clostridium difficile infection (CDI) causes substantial morbidity and healthcare expenditure across Europe. UK prevalence of C. difficile PCR ribotype 027 (NAP1) has declined dramatically recently and other ribotypes have emerged, including ribotype 002 (CD002); now the most prevalent UK ribotype. CD002 is also responsible for CDI in many countries across Europe, including: France, Germany, Ireland, and The Netherlands. We assessed the in vitro phenotypic characteristics of CD002 from across Europe to determine traits that may contribute to its increasing clinical prevalence. Material/methods: Sixty CD002 were studied: UK isolates from 2007-2008 (geographically distinct, N=15), UK isolates from 2011-2013 (19 locations, N=22), and non-UK European isolates from 2012-2014 (N=23, 20 locations). Antimicrobial susceptibilities (13 antimicrobials) were evaluated using an agar incorporation method. Maximum specific growth rates (μmax) were calculated and cytotoxin titres (log10-relative units, RU) determined using Vero cell cytotoxicity assays. Biofilm formation was quantified using 96-well microtitre plate assays and sporulation capacities assessed in liquid culture by quantifying spore-formation over 120 h (CFU/mL). Results: All isolates were susceptible metronidazole, vancomycin, tetracycline and linezolid (MICs ≤2 mg/L). Clindamycin resistance (MIC ≥8 mg/L) was more common in non-UK CD002 (30%) than UK strains (5-13%). Resistance to erythromycin, clarithromycin, nitrofurantoin, chloramphenicol, and moxifloxacin was uncommon (5-7%). MICs for penicillin’s remained below resistance breakpoints, regardless of origin, in all but one isolate (ampicillin MIC 2 mg/L). All CD002 were resistant to trimethoprim (MICs >128 mg/L) and ciprofloxacin (MICs ≥8 mg/L). One MDR strain (UK, 2007) was observed that was macrolide, fluoroquinolone, ampicillin, and nitrofurantoin resistant. Significantly faster μmax was seen in non-UK CD002 (0.92 ±0.058 h-1) than recent/older UK strains (0.76 ±0.063/0.69 ±0.028 h-1 respectively) (P<0.001). Cytotoxin production did not differ significantly (median titres 2-3 RU) between CD002 groups. Recent UK/non-UK CD002 formed significantly greater biofilms by 3 days than asynchronous UK CD002 (P<0.001). Sporulation studies demonstrated that recent UK/non-UK CD002 sporulated more at 24 h than older UK CD002; 18.6-fold/31.2-fold respectively (P<0.05), but by 120 h sporulation did not differ. Conclusions: Recent CD002 from diverse European locations were assessed for traits that may help to explain emergence of CD002 in the UK and compared to asynchronous CD002. Previous studies demonstrated elevated CD002 μmax compared to hypervirulent ribotypes 027/078; and the present study demonstrated that recent non-UK CD002 μmax were significantly further elevated vs. UK isolates. Non-UK CD002 were more clindamycin resistant, but other antimicrobial susceptibilities were similar between CD002 groups. Recent CD002 demonstrated significantly increased sporulation capacities at 24 h and more extensive 3 day biofilm formation compared to asynchronous UK CD002, which could enhance their survival and transmission early in an episode CDI. Further phenotypic and genetic studies are required to evaluate further characteristics of CD002 that may be associated with its emergence in the UK.Peer reviewedFinal Published versio
Upon the existence of short-time approximations of any polynomial order for the computation of density matrices by path integral methods
In this article, I provide significant mathematical evidence in support of
the existence of short-time approximations of any polynomial order for the
computation of density matrices of physical systems described by arbitrarily
smooth and bounded from below potentials. While for Theorem 2, which is
``experimental'', I only provide a ``physicist's'' proof, I believe the present
development is mathematically sound. As a verification, I explicitly construct
two short-time approximations to the density matrix having convergence orders 3
and 4, respectively. Furthermore, in the Appendix, I derive the convergence
constant for the trapezoidal Trotter path integral technique. The convergence
orders and constants are then verified by numerical simulations. While the two
short-time approximations constructed are of sure interest to physicists and
chemists involved in Monte Carlo path integral simulations, the present article
is also aimed at the mathematical community, who might find the results
interesting and worth exploring. I conclude the paper by discussing the
implications of the present findings with respect to the solvability of the
dynamical sign problem appearing in real-time Feynman path integral
simulations.Comment: 19 pages, 4 figures; the discrete short-time approximations are now
treated as independent from their continuous version; new examples of
discrete short-time approximations of order three and four are given; a new
appendix containing a short review on Brownian motion has been added; also,
some additional explanations are provided here and there; this is the last
version; to appear in Phys. Rev.
The ANU WiFeS SuperNovA Program (AWSNAP)
This paper presents the first major data release and survey description for
the ANU WiFeS SuperNovA Program (AWSNAP). AWSNAP is an ongoing supernova
spectroscopy campaign utilising the Wide Field Spectrograph (WiFeS) on the
Australian National University (ANU) 2.3m telescope. The first and primary data
release of this program (AWSNAP-DR1) releases 357 spectra of 175 unique objects
collected over 82 equivalent full nights of observing from July 2012 to August
2015. These spectra have been made publicly available via the WISeREP supernova
spectroscopy repository. We analyse the AWSNAP sample of Type Ia supernova
spectra, including measurements of narrow sodium absorption features afforded
by the high spectral resolution of the WiFeS instrument. In some cases we were
able to use the integral-field nature of the WiFeS instrument to measure the
rotation velocity of the SN host galaxy near the SN location in order to obtain
precision sodium absorption velocities. We also present an extensive time
series of SN 2012dn, including a near-nebular spectrum which both confirms its
"super-Chandrasekhar" status and enables measurement of the sub-solar host
metallicity at the SN site.Comment: Submitted to Publications of the Astronomical Society of Australia
(PASA). Spectra publicly released via WISeREP at
http://wiserep.weizmann.ac.il
Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator secretion from visceral AT and the initiation of pro-inflammatory events that induce oxidative stress and tissue dysfunction. Current understanding supports that suppressing pro-inflammatory and oxidative events promotes improved metabolic and cardiovascular function. In this regard, electrophilic nitro-fatty acids display pleiotropic anti-inflammatory signalling actions. Methods and results It was hypothesized that high-fat diet (HFD)-induced inflammatory and metabolic responses, manifested by loss of glucose tolerance and vascular dysfunction, would be attenuated by systemic administration of nitrooctadecenoic acid (OA-NO2). Male C57BL/6j mice subjected to a HFD for 20 weeks displayed increased adiposity, fasting glucose, and insulin levels, which led to glucose intolerance and pulmonary hypertension, characterized by increased right ventricular (RV) end-systolic pressure (RVESP) and pulmonary vascular resistance (PVR). This was associated with increased lung xanthine oxidoreductase (XO) activity, macrophage infiltration, and enhanced expression of pro-inflammatory cytokines. Left ventricular (LV) end-diastolic pressure remained unaltered, indicating that the HFD produces pulmonary vascular remodelling, rather than LV dysfunction and pulmonary venous hypertension. Administration of OA-NO2 for the final 6.5 weeks of HFD improved glucose tolerance and significantly attenuated HFD-induced RVESP, PVR, RV hypertrophy, lung XO activity, oxidative stress, and pro-inflammatory pulmonary cytokine levels. Conclusions These observations support that the pleiotropic signalling actions of electrophilic fatty acids represent a therapeutic strategy for limiting the complex pathogenic responses instigated by obesity.Fil: Kelley, Eric E.. University of Pittsburgh; Estados UnidosFil: Baust, Jeff. University of Pittsburgh; Estados UnidosFil: Bonacci, Gustavo Roberto. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Córdoba. Centro de Investigaciones en BioquÃmica ClÃnica e InmunologÃa; ArgentinaFil: Golin Bisello, Franca. University of Pittsburgh; Estados UnidosFil: Devlin, Jason E.. University of Pittsburgh; Estados UnidosFil: Croix, Claudette M. St.. University of Pittsburgh; Estados UnidosFil: Watkins, Simon C.. University of Pittsburgh; Estados UnidosFil: Gor, Sonia. University of Pittsburgh; Estados UnidosFil: Cantu Medellin, Nadiezhda. University of Pittsburgh; Estados UnidosFil: Weidert, Eric R.. University of Pittsburgh; Estados UnidosFil: Frisbee,Jefferson C.. University of Virginia; Estados UnidosFil: Gladwin, Mark T.. University of Pittsburgh; Estados UnidosFil: Champion, Hunter C.. University of Pittsburgh; Estados UnidosFil: Freeman, Bruce A.. University of Pittsburgh; Estados UnidosFil: Khoo, Nicholas K.H.. University of Pittsburgh; Estados Unido
Wide-field dynamic astronomy in the near-infrared with Palomar Gattini-IR and DREAMS
There have been a dramatic increase in the number of optical and radio transient surveys due to astronomical transients such as gravitational waves and gamma ray bursts, however, there have been a limited number of wide-field infrared surveys due to narrow field-of-view and high cost of infrared cameras, we present two new wide-field near-infrared fully automated surveyors; Palomar Gattini-IR and the Dynamic REd All-sky Monitoring Survey (DREAMS). Palomar Gattini-IR, a 25 square degree J-band imager that begun science operations at Palomar Observatory, USA in October 2018; we report on survey strategy as well as telescope and observatory operations and will also providing initial science results. DREAMS is a 3.75 square degree wide-field imager that is planned for Siding Spring Observatory, Australia; we report on the current optical and mechanical design and plans to achieve on-sky results in 2020. DREAMS is on-track to be one of the first astronomical telescopes to use an Indium Galium Arsenide (InGaAs) detector and we report initial on-sky testing results for the selected detector package. DREAMS is also well placed to take advantage and provide near-infrared follow-up of the LSST
The Distribution of Mass in the Orion Dwarf Galaxy
Dwarf galaxies are good candidates to investigate the nature of Dark Matter,
because their kinematics are dominated by this component down to small
galactocentric radii. We present here the results of detailed kinematic
analysis and mass modelling of the Orion dwarf galaxy, for which we derive a
high quality and high resolution rotation curve that contains negligible
non-circular motions and we correct it for the asymmetric drift. Moreover, we
leverage the proximity (D = 5.4 kpc) and convenient inclination (47{\deg}) to
produce reliable mass models of this system. We find that the Universal
Rotation Curve mass model (Freeman disk + Burkert halo + gas disk) fits the
observational data accurately. In contrast, the NFW halo + Freeman disk + gas
disk mass model is unable to reproduce the observed Rotation Curve, a common
outcome in dwarf galaxies. Finally, we attempt to fit the data with a MOdified
Newtonian Dynamics (MOND) prescription. With the present data and with the
present assumptions on distance, stellar mass, constant inclination and
reliability of the gaseous mass, the MOND "amplification" of the baryonic
component appears to be too small to mimic the required "dark component". The
Orion dwarf reveals a cored DM density distribution and a possible tension
between observations and the canonical MOND formalism.Comment: 8 pages, 9 figures, accepted for publication in MNRA
Application of <sup>14</sup>C analyses to source apportionment of carbonaceous PM<sub>2.5</sub> in the UK
Determination of the radiocarbon (<sup>14</sup>C) content of airborne particulate matter yields insight into the proportion of the carbonaceous material derived from fossil and contemporary carbon sources. Daily samples of PM<sub>2.5</sub> were collected by high-volume sampler at an urban background site in Birmingham, UK, and the fraction of <sup>14</sup>C in both the total carbon, and in the organic and elemental carbon fractions, determined by two-stage combustion to CO<sub>2</sub>, graphitisation and quantification by accelerator mass spectrometry. OC and EC content was also determined by Sunset Analyzer. The mean fraction contemporary TC in the PM<sub>2.5</sub> samples was 0.50 (range 0.27–0.66, n = 26). There was no seasonality to the data, but there was a positive trend between fraction contemporary TC and magnitude of SOC/TC ratio and for the high values of these two parameters to be associated with air-mass back trajectories arriving in Birmingham from over land. Using a five-compartment mass balance model on fraction contemporary carbon in OC and EC, the following average source apportionment for the TC in these PM<sub>2.5</sub> samples was derived: 27% fossil EC; 20% fossil OC; 2% biomass EC; 10% biomass OC; and 41% biogenic OC. The latter category will comprise, in addition to BVOC-derived SOC, other non-combustion contemporary carbon sources such as biological particles, vegetative detritus, humic material and tyre wear. The proportion of total PM<sub>2.5</sub> at this location estimated to derive from BVOC-derived secondary organic aerosol was 9–29%. The findings from this work are consistent with those from elsewhere in Europe and support the conclusion of a significant and ubiquitous contribution from non-fossil biogenic sources to the carbon in terrestrial aerosol
GNOSIS: the first instrument to use fibre Bragg gratings for OH suppression
GNOSIS is a prototype astrophotonic instrument that utilizes OH suppression
fibres consisting of fibre Bragg gratings and photonic lanterns to suppress the
103 brightest atmospheric emission doublets between 1.47-1.7 microns. GNOSIS
was commissioned at the 3.9-meter Anglo-Australian Telescope with the IRIS2
spectrograph to demonstrate the potential of OH suppression fibres, but may be
potentially used with any telescope and spectrograph combination. Unlike
previous atmospheric suppression techniques GNOSIS suppresses the lines before
dispersion and in a manner that depends purely on wavelength. We present the
instrument design and report the results of laboratory and on-sky tests from
commissioning. While these tests demonstrated high throughput and excellent
suppression of the skylines by the OH suppression fibres, surprisingly GNOSIS
produced no significant reduction in the interline background and the
sensitivity of GNOSIS and IRIS2 is about the same as IRIS2. It is unclear
whether the lack of reduction in the interline background is due to physical
sources or systematic errors as the observations are detector noise-dominated.
OH suppression fibres could potentially impact ground-based astronomy at the
level of adaptive optics or greater. However, until a clear reduction in the
interline background and the corresponding increasing in sensitivity is
demonstrated optimized OH suppression fibres paired with a fibre-fed
spectrograph will at least provide a real benefits at low resolving powers.Comment: 15 pages, 13 figures, accepted to A
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